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CPTH6 hydrobromide
CAS No. ——
CPTH6 hydrobromide ( —— )
产品货号. M17047 CAS No. ——
CPTH6 Hydrobromide 是一种噻唑衍生物，可以降低人白血病细胞中的组蛋白乙酰化和组蛋白乙酰转移酶 (HAT) 活性。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | 获取报价 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称CPTH6 hydrobromide
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述CPTH6 Hydrobromide 是一种噻唑衍生物，可以降低人白血病细胞中的组蛋白乙酰化和组蛋白乙酰转移酶 (HAT) 活性。
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产品描述CPTH6 hydrobromide is a thiazole derivative that can reduce histone acetylation and histone acetyltransferase (HAT) activity in human leukemia cells, CPTH6 is a specific Gcn5/pCAF inhibitor; CPTH6 exerts a significant inhibitory effect on HAT activity of both pCAF and Gcn5, whereas it does not affect p300 and CBP HAT activity; decrease acetylation of histone H3 specifically at lysine 18 in a dose-dependent fashion, does not affect H3 histone methylation at lysines 9 and 4; induces cell-cycle perturbation and apoptosis in AML cells, induces differentiation in AML and neuroblastoma cells; impairs autophagy and reduces autophagosome turnover through an impairment of their degradation pathway.
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体外实验——
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体内实验——
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同义词——
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通路Chromatin/Epigenetic
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靶点HAT
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受体HAT
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研究领域——
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适应症——
化学信息
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CAS Number——
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分子量386.736
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分子式C15H17BrClN3S
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纯度>98% (HPLC)
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溶解度——
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SMILES——
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化学全称(E)-4-(4-chlorophenyl)-2-(2-(3-methylcyclopentylidene)hydrazinyl)thiazole hydrobromide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Trisciuoglio D, et al. Clin Cancer Res. 2012 Jan 15;18(2):475-86.
2. Ragazzoni Y, et al. Cell Death Dis. 2013 Mar 7;4:e524.
3. Di Martile M, et al. Oncotarget. 2016 Mar 8;7(10):11332-48.
4. Chimenti F, et al. J Med Chem. 2009 Jan 22;52(2):530-6.
